The Endocannabinoid System and How it Works

The human body usually produces a component called cannabinoids, which is a component also found in cannabis. Despite the latter, much research has shown how important this component is for the human body and its functions. 

So just as our body is able to produce CBD, we have an endocannabinoid system that runs throughout our body, which has several receptors capable of capturing the CBD and so it enters our bloodstream, which is why the best organic CBD oil works so many wonders. Here we will talk more about how this system works.

What is the endocannabinoid system?

The endogenous cannabinoid system, named after the plant that contributed to its discovery, is one of the most essential physiologic systems involved in human health establishment and maintenance. Endocannabinoids and their receptors can be present in the brain, organs, connective tissues, glands, and immune cells, among other places. 

The endocannabinoid system performs various functions in different tissues. The target, however, is often the same: homeostasis, or maintaining a stable internal climate despite external fluctuations.

How the endocannabinoid system works

The endocannabinoid system is composed of several integrated mechanisms, such as the ones we will discuss below:

  • Enzymes are responsible for the creation and destruction of cannabinoids.
  • Receptor sites in cells to receive cannabinoids.
  • Endocannabinoids (cannabinoid-like compounds that occur naturally in the human body).
  • These mechanisms are predominantly responsible for communication within the body to better regulate various biological responses.

As discussed above, compounds called phytocannabinoids, such as THC and CBD, which are found in the cannabis plant, also come to be produced by the body in the form of the endocannabinoids anandamide and 2-AG, which are like the two prominent analogs of THC and CBD.

How CBD affects the system

CBD, being also a chemical compound in our body, presents effects to the body by binding to receptors found on the surface of cells, proteins anchored to the cell membrane that act as signal transducers across the cell membrane, thus initiating certain physiological responses. In a simile, these receptors act as “access locks” to cells; and when activated by compounds that fit into these locks, they tell the cell what to do or not to do.

Thus, these cell receptors modulate the release of neurotransmitters and hormones that regulate different biological processes in our body systems.

In the case of the human endocannabinoid system, the most important is the type 1 cannabinoid receptor (usually abbreviated as CB1) which reside in the central nervous system (brain and spinal cord nerves); and type 2 (CB2), which is concentrated in the peripheral nervous system, consisting of the nerves located in the rest of the body (allowing the brain to communicate with these areas), as well as the digestive and immune systems.

However, CB1 receptors are more common in the central nervous system and are related to certain benefits for the human body, such as modulation of stress and anxiety, increases appetite, decreases nausea, has the ability to balance the immune system, and one of the latest discoveries regarding this system and in relation to CB1 is that it can inhibit tumors. 

On the other hand, CB2 receptors are found primarily on immune system cells and appear to dominate the fight against inflammation and tissue damage. Some cells may even contain both types of receptors, each responsible for a different function.

Reason for taking CBD oil

As we already know, CBD is a component coming from cannabis, the use of CBD oil has been legalized in many countries due to its many medical benefits. However, there is still a lot of controversy as to whether it should be taken only for medical purposes, or also recreationally. 

Over the years, the importance of CBD oil for the maintenance of normal bodily functions has been demonstrated. As already mentioned, cannabinoids are produced naturally in the body and are important for homeostasis. Therefore, more and more doctors are suggesting taking CBD oil for medical purposes and including them in the routine. 

Remembering that some of the benefits of CBD for the human body are that it relieves anxiety and stress, helps with chronic pain, improves memory, stops bacterial growth, helps with sleep, is anti-inflammatory, and just like these, more and more benefits of cannabinoid for the human body are being discovered. 


Overall, research indicates that the endocannabinoid system helps ensure that the body’s immune system and central nervous system function properly. Remembering that the endocannabinoid system can be used therapeutically to decrease pain, fight cancer, prevent neurodegenerative diseases, promote health. 

As we have already seen, CBD has many health benefits, and ingesting it will not cause any severe harm. However, before using it, it is important to get medical advice.

William Stash Jones

William "Stash" Jones is a medical marijuana patient and medical cannabis advocate. He focuses on medical cannabis and its benefits, and believes that medical cannabis is the solution to many problems in medicine today.

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